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The results of 8 trials suggested some beneficial effect of Selegiline in the treatment of cognitive deficits and in 3 trials in the treatment of behaviour and mood. Quantitative analysis of desmethylSelegiline, methamphetamine, and amphetamine in hair and plasma from Parkinson patients on long-term Selegiline medication.

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Selegiline is used to help control the symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) in people who are taking levodopa and carbidopa combination (Sinemet). Selegiline may help people with Parkinson's disease by decreasing the dose of levodopa/carbidopa needed to control symptoms, stopping the effects of levodopa/carbidopa from wearing off between doses, and increasing the length of time that levodopa/carbidopa will continue to control symptoms. Selegiline is in a group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.

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