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Amodex (Augmentin)

Amodex (amoxicillin + clavulanic acid) is widely used in the treatment of odontogenic infection. Therefore, this study is designed to generate data to support its use by demonstrating efficacy, safety and tolerability in comparison with clindamycin in subjects with acute odontogenic infections with or without abscess. This will be a two-arm, parallel, comparative, observer blind, randomised study to assess efficacy, safety and tolerability of amoxicillin + clavulanic acid (875mg/125mg) in comparison with clindamycin (150mg) administered for 5-7 days in subjects with acute odontogenic infections with or without abscess. The study will be performed in adult subjects both male and female ≥18 years of age who present with acute odontogenic infections. A total of 472 subjects will be randomized in 1:1 ratio, i.e. 236 subjects in each treatment arm. The treatment duration of the study will be at least 5 days or maximum 7 days depending upon the treatment response. Subjects will be assessed on Day 5 and if Investigator feels the need of continuing the treatment at Day 5 then treatment will be continued till Day 7. For subjects who do not show treatment response on Day 5, assessments will be performed on Day 7.

Other names for this medication:
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Take Amodex exactly according to your doctor’s instructions. You might start to feel better before you finish your entire treatment. But even if you do feel better, don’t stop taking Amodex. In many cases, it’s important to finish the entire treatment to ensure that the infection does not come back.

If you’re feeling better and want to stop Amodex early, be sure to ask your doctor if it’s safe to do so.


Amodex is taken two or three times daily. If you take it twice daily, spread out the doses so that they’re roughly 12 hours apart. If you take it three times daily, spread out the doses so that they’re roughly eight hours apart.

Amodex XR is taken twice daily. Spread out the doses so that they’re about 12 hours apart.

Taking Amodex with food

You can take Amodex on an empty stomach or with a meal. Taking it with a meal may reduce stomach upset and help your body absorb the drug better.

You should take Amodex XR at the start of a meal. This increases the amount of medication your body absorbs and helps reduce stomach upset.

Can Amodex be crushed?

Amodex can be crushed. However, Amodex XR should not be crushed. If either type of tablet is scored (has an indented line across it), it can be split in half.

If you have trouble swallowing pills, ask your doctor or pharmacist about taking Amodex liquid suspension instead.

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