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Bicusan (Bicalutamide)
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Bicalutamide

Bicusan is a hormone-based chemotherapy. The NCI Drug Dictionary defines the compound as a “synthetic, nonsteroidal anti-androgen. Bicusan competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors.” Bicusan is used in combination with other agonists like leuprolide or goserelin for the treatment of metastatic prostate cancer. It works by blocking the normal effect of the male hormone androgen. The main type of androgens produced by the body are testosterone and dihydrotestosterone (DHT). These are formed in testes, adrenal glands and tumors themselves, and they stimulate the growth of prostate cancer cells. Bicusan blocks this ability in order to stop the growth and spread of cancer.

Other names for this medication:
Bicalutamide, Casodex, Bicalox, Bicalutamida, Bicusan, Bidrostat, Caluran, Calutide, Calutol, Capro, Cosudex, Imda, Lutamidal, Probic, Zolacos,

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Bicusan is used together with a luteinizing hormone releasing hormone (LHRH) analog (eg, goserelin or leuprolide) to treat stage D2 metastatic prostate cancer (cancer that has spread) in men. Bicusan belongs to the group of medicines called antiandrogens. It works by blocking the effects of testosterone (a male hormone), which helps stop the growth and spread of cancer cells.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

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Soft-tissue coverage and vascularity likely play a vital role in the genesis of wound complications and infections during open Achilles tendon repair. Brain-derived neurotrophic factor (BDNF) haploinsufficiency is associated with hyperphagia and obesity in both animals and humans.

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MicroRNAs (miRNAs) are small, noncoding RNAs involved in posttranscriptional regulation of protein-coding genes in various biological processes. Hemodynamic imaging methods give information about brain dynamics on a much slower scale, and established techniques for imaging brain dynamics in all modalities forbid participants from making natural extensive movements so as to avoid intractable movement-related artifacts.

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The authors recall that excision of liver tissue may be unavoidable in some cases due to the severity and consequences of lithiasis. A surgical robotic system was able to perform routine procedures to remove a polyp in the vocal cord under clinically realistic conditions on an adult phantom. The secondary outcome measure was general blood test, coagulation assay, and plasma fibrinogen, and these were analyzed also using the analysis of variance.

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The effects of anxiety and strategic planning on visual search behaviour. In the first section of the paper, empirical studies that document the prevalence of smoking and panic-related problems are presented and discussed.

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They largely contribute to the regulation of bone remodeling in response to mechanical and microenvironmental changes. Two systems for evaluating hospital laundry hygiene were combined: HACCP principles (hazard analysis and critical control points) and RAL-GZ 992 standards (quality assurance standard for textile care of hospital laundry). The OusB components showed a significant degree of sequence identity to components of ProU from Salmonella enterica serovar Typhimurium and Escherichia coli.

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A software package for the manipulation, display and analysis of electron and light microscope data. Meta-analysis of the effect of intravitreal bevacizumab in branch retinal vein occlusion. Clinical prognostic factors for tinnitus retraining therapy with a sound generator in tinnitus patients. Every fifth patient with retinal ablation was referred by a doctor of family medicine.

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Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death. Indications include cognition and memory in Alzheimer disease, age-associated dementia, cerebral insufficiency, intermittent claudication, schizophrenia, and multi-infarct dementia. Due to the lack of appropriate biological reference material, road dust (BCR-723) was used for method validation. Two types of polypyrrole (PPy)-based calcium sensors are presented, one sensor with PPy-calcion film as the active part and the other sensor with PPy-calcion as a solid-state contact coated with a conventional membrane selective towards calcium ions.

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Kinetic flow-injection determination of hydrogen peroxide by use of iron(III)-catalyzed coloration and its application to the determination of biological substances. Assessment of the effect of a high-fat meal on the pharmacokinetics of sustained release metoclopramide. Change in FIMtrade mark instrument scores, home discharge rate, and rehabilitation length of stay (LOS.) From in silico analyses, domain swapping and rational protein engineering experiments, evidence has accumulated that indicates that J domains contain key specificity determinants. Concomitant abdominal CT scan disclosed large peripancreatic hypodensities without pneumoperitoneum.

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Drug-induced lipidosis in human cases and in animal experiments. Perceived benefits and barriers, as central constructs in some patterns and theories of behavior change, were related to self-care, so that it was directly related to perceived benefits and reversely related to perceived barriers. PROBLEMS CONNECTED WITH PHYSICAL EXAMINATIONS FOR PREGNANT WOMEN The results demonstrated that the interaction between SA and protein was mainly contributed by hydrogen bonding and hydrophobic forces.

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The main outcome variable was relationship dissolution in the 39-month period from gestational week 30-36 months postpartum. Further prospective studies are required to examine the effectiveness and long-term outcomes of anti-TNFalpha therapy in this cohort. Patellar bracing did not improve the symptoms of PFPS more quickly when added to a home program of leg strengthening. Functional receptor characterization demonstrated major divergence in pharmacological behavior for Mc4r receptors encoded by different copies of platyfish mc4r, with differences in constitutive activity as well as binding and stimulation by hormones. We find evidence of positive selection associated with all six Adam genes known to interact to form functional complexes on Mus sperm.

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Scanning electron microscopy was employed to evaluate the morphology of S. The purpose of this review is to examine some of the latest concepts in the management of sepsis and septic shock in the Intensive Care environment, with a focus on Gram-negative infections.

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A choice of simple and more flexible user-friendly Boolean search features allows researchers to search and compare annotations or sequences within or between genomes. Ovarian cancer antigen CA 125 levels in pelvic inflammatory disease and pregnancy. A comparative study of the parasitological techniques: Kato-Katz and coprotest High resolution inductively coupled plasma mass spectrometry allows rapid assessment of iron absorption in infants and children. With the recent advances in genomic medicine and the development of targeted antiangiogenic therapy for cancer patients, there has been an increased interest in the role of predictive and prognostic markers for antiangiogenic therapy.

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The conventional antibody origin of these V(H)s was confirmed by using oligonucleotide probes, specific for the enriched V(H)s, to identify the parental sequences in the message employed in library construction. NORMAL PREGNANCY AND LABOR AFTER RADIOACTIVE IODINE TREATMENT FOR EXOPHTHALMIC GOITER Use of milk amyloid A in the diagnosis of subclinical mastitis in dairy ewes.

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The differential sensitivity of Hymenolepis microstoma (Cestoda: Cyclophyllidea) Cysticercoid stages to X-rays. The flexibility of the HQCal was demonstrated using surgical site infections after abdominal surgery and postoperative surgical airway complications. We use angle-resolved photoemission spectroscopy to show that the two-gap behavior and the destruction of well-defined electronic excitations are not universal features of HTSCs, and depend sensitively on how the underdoped materials are prepared.

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The objective of the present study was to provide further insight into the biological function of BTG2(TIS21/PC3) by determining the expression levels and cellular localization of BTG2(TIS21/PC3) in a spectrum of normal human tissues and to determine the proliferative indices (based on Ki-67 staining) and apoptotic indices (based on TUNEL assay) in those cell populations where BTG2(TIS21/PC3) was differentially expressed. Cognitive performance on the mini-mental state examination and the montreal cognitive assessment across the healthy adult lifespan. The results suggest that provided the refractive index of breast tissue is approximately 1.3-1.4, their exclusion will have minimal effect on the reconstructed images. It was reported that expansive pedicle screw (EPS) and polymethylmethacrylate-augmented pedicle screw (PMMA-PS) could be used to increase screw stability in osteoporosis.

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PGD2 dose dependently potentiated the parasympathetic-induced contraction in guinea-pig trachea in vitro. Effects of a selective glucocorticoid receptor agonist on experimental keratoplasty. The present study aimed to observe the effect on these variables of different semioccluded vocal tract postures in 20 subjects diagnosed with hyperfunctional dysphonia. Gingival lesions could be one of the first manifestations of LCH. One case of transdiafragmatic intercostal hernia after intense coughing fit followed by rib fractures in patient with history of pneumonia is presented.

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Furthermore, the similarities of this phenotype to accelerated aging-related thymic involution support the possibility that changes in Foxn1 expression in TECs during aging contribute to the mechanism of involution. The loss of biologic fusion at the bone-implant interface and prosthetic failures have been reported in previous artificial discs. HA oligomers modulate inflammatory processes and promote neo-angiogenesis during the different steps of wound healing. Chromosomal abnormalities in an anholocyclic biotype of Myzus persicae (Sulzer). Contemporary estimates of the prevalence of CHB in Australia are essential to guide appropriate public health and clinical responses.

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To describe the occurrence of dental caries and periodontal conditions among standards three and four primary school children in Morogoro municipality and compare the obtained oral health indicators with the goals stipulated in the National Plan for Oral Health by the year 2002. A second possible scenario for temperature-independent hole mobility involves the competion between two different polaron mechanisms involving so-called nearly small molecular polarons and small lattice polarons. cerevisiae (yeast) strains to investigate genome variation in natural and artificial environments.

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Traditional clinical stages of wounding healing are still relevant, but more overlap between stages is likely a more accurate depiction of events. Prior to minimally invasive surgery, 24 (15 females, 9 males) nonresponders underwent a repetitive iodine starch test to define the area of recurrent sweating.

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The results suggested there were no serum lipid profiles used as biological markers to distinguish the clinical subtypes, suicide attempts and episodes in patients with major depression. The effects of imatinib mesylate, alone and combined with the alklyating agent, temozolomide, were examined in vivo as well as in vitro. Understanding family dynamics and relationship is an important facet of care, therapeutic education and psychosocial support.

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This cadaver-based study suggests an insertion point closer to the ASIS, approximately 2.5 mm (range: 1.0-4.9) from the ASIS on a line drawn between the ipsilateral ASIS and the umbilicus. Increased education during undergraduate training regarding use of formative assessment may lead to more effective utilisation in the postgraduate setting. Increasing incidence of multiple sclerosis in the province of Sassari, northern Sardinia.

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Comparative radioligand analysis of gene-engineered and human hypophyseal somatotropic hormones Three-dimensional controlled interstitial hyperthermia combined with radiotherapy for locally advanced prostate carcinoma--a feasibility study. Either antegrade biliary stenting (ABS) or antegrade balloon dilation (ABD) was performed depending on the biliary disorders. All stone events which occurred prior to referral, then after entry in the study were recorded.

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EFFECT OF A THIAZOLIDINIC DERIVATIVE OF PYRIDOXAL PHOPHATE ON THE RESPIRATION OF VARIOUS TISSUES Many of the resulting changes are due to changes in resource allocation that come with infection. Plaque was then scored using the Turesky modification of the Quigley-Hein Index, and subjects were instructed to brush their teeth for a total time of 1 minute with either one or the other brush, according to a predetermined randomization schedule. The goal of the study was to generate findings that would provide the basis for implementing system-wide changes to include culturally competent care. An ex vivo assay to assess the potential of skin keratinocytes for wound epithelialization.

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Moreover, the role of inflammation has recently been advanced as pivotal in OA onset and progression. In erythroleukaemia cells, there is both a continuous proliferation and a synthesis of haem, and these cell lines are therefore especially interesting for studies on iron metabolism.

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However, of the hundreds of differentially expressed proteins, only few may have clinical utility and thus function as biomarkers. We investigate postural sway data dynamics in older adult fallers and non-fallers. We report a case of a 71-year-old woman with cerebral infarction due to occlusion of the internal carotid artery (ICA) caused by a neck tumor.

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Bench-to-bedside review: Therapeutic options and issues in the management of ventilator-associated bacterial pneumonia. The plasma concentrations of progesterone and dehydroepiandrosterone were greater in drug-free patients than in controls, whereas those of allopregnanolone and tetrahydrodeoxycorticosterone did not differ between the two groups.

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This guideline is intended for all clinicians who are likely to diagnose and manage 400 mg quetiapine seroquel adults with BPPV. Myocardial fibrosis may represent a pathologic substrate that determines LV functional reserve in patients with HCM. Melanoma incidence is associated with increased UV index and lower latitude only in non-Hispanic whites. The biceps brachii and brachialis muscles comprise a large muscular complex.

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The aim of this study was to compare the relative importance of donor versus recipient factors on post-orthotopic liver transplantation xanti medicine shoppe survival among HCC and non-HCC recipients. A unified model for the dynamics of driven ribbon with strain and magnetic order parameters.

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Complexes of heparin with elastomeric positive polyelectrolytes. Structural and biochemical characterization of a halophilic archaeal alkaline phosphatase. Effects of the diuretics, triamterene and mersalyl on active sodium transport mechanisms in isolated frog skin. MS was defined according to the National Cholesterol Education Program buproban generic cymbalta Adult Treatment Panel III.

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The development of prosthetic disc replacements is an exciting area of research, but clinical results have not approached the success currently enjoyed by hip and knee prostheses, and these devices should be considered experimental. Underlying respiratory disease does not affect the negative predictive value of thin-collimation CT angiography, which appears to be a reliable tool in the work-up in this subgroup of patients with acute PE. contraindications for zestril prinivil The overall survival of esophageal carcinoma patients undergoing 3D-CRT was promising.

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